Molecular Connections today announced the licensing of NetPro™, the completely, hand-curated knowledgebase of protein interactions to Dr. David Eisenberg’s research Lab at DOE Institute for Genomics and Proteomics, UCLA.
NetPro™, Molecular Connections’ proprietary protein interaction knowledgebase covers more than 30,000 expert curated and annotated protein-protein interactions from published biomedical literature. Molecular Connections will issue subsequent updates to the database, on a regular basis.
All the interactions have been validated through expert curation by Molecular Connections’ in-house scientific team. All molecules in NetPro™ are linked to public Ids (like LocusLink), facilitating ready integration of interactions information into proprietary databases. The protein-protein interactions in NetPro™ are complemented with annotations of the profiled proteins with scientific literature information on a variety of important subjects, including Biological Pathways/sub-pathways, Species, Experimental Technique, Diseases implicated etc.
NetPro™ is increasingly becoming a critical input for various academic and commercial labs around the world studying interaction/pathways data for augmenting their systems biology initiatives.
Protein interactions play significant roles in various aspects of the structural and functional organization of the cell, and their elucidation sheds light on the molecular mechanisms of biological processes. Having a database of protein interactions will allow researchers to identify drugs that target pathways related to a specific disease while avoiding pathways associated with unwanted side effects and toxicity. Key to advancing our knowledge of biochemical pathways and networks is the intelligent analysis and mining of available literature, which is a large untapped resource containing information about thousands of interactions.